反应详情

温度

28 °C

To methyl 4-(3-piperidin-1-ylpropoxy)benzoate ax15 (4.41 g, 15.9 mmol, 1 eq) in ethanol (160 ml) is added a 5 N aqueous solution of sodium hydroxide (9.54 ml, 47.7 mmol, 3 eq) and the mixture is stirred at 60° C. for 4 h and at 28° C. overnight. The mixture is concentrated under vacuum to give a white solid, which is then dissolved in a 1:1 mixture of ethanol/water (100 ml). A solution of 5 N aqueous hydrochloric acid is then added until the pH of the mixture reaches 2-3. The ethanol is then evaporated under vacuum and the mixture filtered to give a white solid. This solid is washed with water and dried under vacuum at 40° C.

1. concentrationThe mixture is concentrated under vacuum
2. customto give a white solid, which
3. customThe ethanol is then evaporated under vacuum
4. filtrationthe mixture filtered
5. customto give a white solid
6. washThis solid is washed with water
7. customdried under vacuum at 40° C.