反应详情

Thionyl chloride (1.55 g, 13.09 mmol, 1.1 equiv.) is added dropwise to 4-(3-chloropropoxy)-N-(2-hydroxy-1,1-dimethylethyl)benzamide ax53 (3.18 g, 11.9 mmol, 1 eq) in dry dichloromethane (100 ml), under a nitrogen atmosphere over 30 min. The solution is then stirred for 3 h. Water and potassium carbonate are finally added and the mixture is stirred until no more bubbles are formed (pH=10). The layers are separated and the dichloromethane layer is washed with brine, dried over sodium sulfate and evaporated under vacuum to give 3.18 g of 2-[4-(3-chloropropoxy)phenyl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole ax10.

1. stirringthe mixture is stirred until no more bubbles
2. customare formed (pH=10)
3. customThe layers are separated
4. washthe dichloromethane layer is washed with brine
5. dry with materialdried over sodium sulfate
6. customevaporated under vacuum