HuagongsheHuagongshe Chemistry Print Report · For research reference only
Reserpine → 2-(Boc-amino)-5-bromopyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Reserpine | HCID 5770 | — |
| Reactant | 2-Amino-5-bromopyridine | HCID 70622 | — |
| Reactant | Tert-butyl (5-bromo-2-methoxyphenyl)carbamate | HCID 17942658 | — |
| Reactant | Ethylacetate heptane | HCID 21899848 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-(Boc-amino)-5-bromopyridine | HCID 16217843 | — |
Reaction Steps
The compound was prepared from 5-bromo-2-pyridinamine in the manner described for compound (2): 1H NMR (DMSO-d6, 400 MHz) δ 9.96 (s, 1H), 8.49 (d, 1H), 7.93 (dd, 1H), 7.78 (d, 1H), 1.47 (s, 9H); TLC (ethyl acetate/heptane 5:95) Rf 0.28; RP-HPLC (Hypersil HyPurity Elite C18, 5 μm, 200 A, 250×4.6 mm; 25-100% acetonitrile-0.1 M ammonium acetate over 25 min, 1 ml/min) tr=18.50 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863444B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-26f8ed8b7a324c9babdcf40b77d73d0b |
| Source note | uspto-grants-2011_01 |