反应详情

温度

100 °C

4-(4-Dimethylaminophenylcarbonyloxymethyl)-2,2-dimethyl-1,3-dioxolane from Example 4 (3 mmol) is dissolved in the diglyme/H2O 8:2 mixture (25 ml), and boric acid (2 g) is added. The reaction mixture is stirred at 100° C. for 3 h. The solvent is then distilled off in vacuo, the crude product which remains is taken up in water (100 ml) and extracted with ethyl acetate (3×20 ml). The combined organic phases are washed with water (2×50 ml) and dried over magnesium sulfate. The crude product remaining after evaporation of the ethyl acetate in vacuo is employed without further purification for subsequent reactions.

1. additionis added
2. distillationThe solvent is then distilled off in vacuo
3. extractionextracted with ethyl acetate (3×20 ml)
4. washThe combined organic phases are washed with water (2×50 ml)
5. dry with materialdried over magnesium sulfate
6. customafter evaporation of the ethyl acetate in vacuo
7. customis employed without further purification for subsequent reactions