Boric Acid → 2,3-Dihydroxypropyl 4-dimethylaminobenzoate

Participants

Reaction Conditions

Reaction Steps

4-(4-Dimethylaminophenylcarbonyloxymethyl)-2,2-dimethyl-1,3-dioxolane from Example 4 (3 mmol) is dissolved in the diglyme/H2O 8:2 mixture (25 ml), and boric acid (2 g) is added. The reaction mixture is stirred at 100° C. for 3 h. The solvent is then distilled off in vacuo, the crude product which remains is taken up in water (100 ml) and extracted with ethyl acetate (3×20 ml). The combined organic phases are washed with water (2×50 ml) and dried over magnesium sulfate. The crude product remaining after evaporation of the ethyl acetate in vacuo is employed without further purification for subsequent reactions.

Provenance & Evidence