反应详情

To a solution of Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxobutyrate (Step C) in tetrahydrofuran, add sodium borohydride dissolved in water, After 3-4 hours of stirring at room temperature, quench with an acid. The organic layer can be taken in dichloromethane, wash with water, aqueous sodium bicarbonate, and brine, dry over Na2SO4, filter and concentrate. If needed, the compound can be purified by flash chromatography on silica gel column (EtOAc:Hex).

1. customquench with an acid
2. washwash with water, aqueous sodium bicarbonate, and brine
3. dry with materialdry over Na2SO4
4. filtrationfilter
5. concentrationconcentrate
6. customthe compound can be purified by flash chromatography on silica gel column (EtOAc:Hex)