反应详情

Example 15 is prepared from pyrrolo[1,2-a]pyrazine-3-carboxylic acid hydrochloride and (3R,5R)-1-azabicyclo[3.2.1]octan-3-amine dihydrochloride using Procedure C to give a mixture purified by silica gel chromatography (9% MeOH/1%NH3OH/CHCl3 as the eluent) salted with fumaric acid, and crystallized from acetone to give a white solid. Yield 83%. HRMS (FAB) calcd for C15H18N4O MH+271.1559, found 271.1550.

1. customto give a mixture
2. custompurified by silica gel chromatography (9% MeOH/1%NH3OH/CHCl3 as the eluent)
3. customcrystallized from acetone
4. customto give a white solid