HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 24774027, compound → HCID 59985812, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 24774027 | HCID 24774027 | — |
| Reactant | Pyrrolo[1,2-a]pyrazine-3-carboxylic acid hydrochloride | HCID 69607044 | — |
| Product | HCID 59985812 | HCID 59985812 | 83% |
Reaction Steps
Example 15 is prepared from pyrrolo[1,2-a]pyrazine-3-carboxylic acid hydrochloride and (3R,5R)-1-azabicyclo[3.2.1]octan-3-amine dihydrochloride using Procedure C to give a mixture purified by silica gel chromatography (9% MeOH/1%NH3OH/CHCl3 as the eluent) salted with fumaric acid, and crystallized from acetone to give a white solid. Yield 83%. HRMS (FAB) calcd for C15H18N4O MH+271.1559, found 271.1550.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06858613B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-f4a2806e6c3941c7818c5630489ed9e7 |
| Source note | uspto-grants-2005_02 |