反应详情

温度

70 °C

A mixture of 4-chloro-6-(2,6-diethyl-phenyl)-2-methyl-nicotinic acid ethyl ester (200 mg, 0.60 mmol) and sodium thiomethoxide (126 mg, 1.80 mmol) in DMF (5 mL) is heated at 70° C. overnight. After cooling, water (20 mL) is added and the resulting mixture is extracted with EtOAc. The combined extracts are washed with brine, dried over sodium sulfate and concentrated. The residue is chromatographed on silica gel to give 6-(2,6-diethyl-phenyl)-2-methyl-4-methylsulfanyl-nicotinic acid ethyl ester.

1. temperatureAfter cooling
2. extractionthe resulting mixture is extracted with EtOAc
3. washThe combined extracts are washed with brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customThe residue is chromatographed on silica gel