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3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile → (3-(Imidazo[1,2-b]pyridazin-2-yl)phenyl)methanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 53439477 | — |
| 触媒 | Nickel | HCID 935 | — |
| 触媒 | Azane;hydrate | HCID 12896473 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (3-(Imidazo[1,2-b]pyridazin-2-yl)phenyl)methanamine | HCID 57686815 | — |
反応手順
Raney-Ni (cat.) and NH3.H2O (4˜5 drops) were added to the solution of 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile (25 mg) in MeOH. The mixture was stirred vigorously at room temperature for 1 h under hydrogen and the Raney-Ni was then removed. The filtration was concentrated in vacuo to give the (3-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanamine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07868001B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-cc75bb5e2a0b4c5c9ef3a32d2d9361db |
| 出典メモ | uspto-grants-2011_01 |