HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 251809Generated: October 26, 2026
Potassium Carbonate → 1-(3-(Imidazo[1,2-b]pyridazin-2-yl)benzyl)-3-(2-morpholinoethyl)urea
https://huagongshe.com/reaction/251809
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 2-Morpholinoethylamine | HCID 408285 | — |
| Reactant | (3-(Imidazo[1,2-b]pyridazin-2-yl)phenyl)methanamine | HCID 57686815 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(3-(Imidazo[1,2-b]pyridazin-2-yl)benzyl)-3-(2-morpholinoethyl)urea | HCID 42624175 | — |
Reaction Steps
0.2 mmol (3-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanamine and 1 mmol K2CO3 in dry Toluene were stirred for 30 min at 30° C., added with CDI (0.2 mmol), and kept to stir for 2 h. Then 0.2 mmol 2-morpholinoethanamine and DMAP (cat.) were added and the solution was heated to 60° C. for 2 h. The reaction was concentrated in vacuo and the residue was purified by column chromatography on silica gel to give the 1-(3-(imidazo[1,2-b]pyridazin-2-yl)benzyl)-3-(2-morpholinoethyl)urea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07868001B2 |
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| Source dataset | uspto-grants-2011_01 |
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| ORD ID | ord-79602e0ce6044303b938308c5a21a875 |
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| Source note | uspto-grants-2011_01 |
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