反应详情

温度

60 °C

0.2 mmol (3-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanamine and 1 mmol K2CO3 in dry Toluene were stirred for 30 min at 30° C., added with CDI (0.2 mmol), and kept to stir for 2 h. Then 0.2 mmol 2-morpholinoethanamine and DMAP (cat.) were added and the solution was heated to 60° C. for 2 h. The reaction was concentrated in vacuo and the residue was purified by column chromatography on silica gel to give the 1-(3-(imidazo[1,2-b]pyridazin-2-yl)benzyl)-3-(2-morpholinoethyl)urea.

1. concentrationThe reaction was concentrated in vacuo
2. customthe residue was purified by column chromatography on silica gel