Potassium Carbonate → HCID 42623100, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-b]pyridazin-6-yl)acetamide(0. 15 mmol) and K2CO3 (0.3 mmol)in 20 mL methanol -water(4:1) was heated at 60° C. for 1 h. The mixture was concentrated in vacuo and the crude product was purified by column chromatography on silica gel to give the N-methyl-2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-b]pyridazin-6-amine.

Provenance & Evidence