Potassium Carbonate → HCID 42623100, compound

HRID 251813Notes

Reaction equation

HRID 251813 reaction equation
FC(F)(F)[C:3]([N:5](C)[C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]4[N:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[O:23][N:22]=4)[CH:16]=3)[N:14]=2)[N:11]=1)=O.C([O-])([O-])=O.[K+].[K+]>CO.O>[CH3:3][NH:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]4[N:25]=[C:24]([C:26]([F:29])([F:27])[F:28])[O:23][N:22]=4)[CH:16]=3)[N:14]=2)[N:11]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86630107HCID 86630107, compound

Product 1

HCID 42623100HCID 42623100, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Conditions

Temperature
60 °C

Procedure

A mixture of 2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-b]pyridazin-6-yl)acetamide(0. 15 mmol) and K2CO3 (0.3 mmol)in 20 mL methanol -water(4:1) was heated at 60° C. for 1 h. The mixture was concentrated in vacuo and the crude product was purified by column chromatography on silica gel to give the N-methyl-2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-b]pyridazin-6-amine.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe crude product was purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-b2a054e640504b918374ef875c4d28b8
Source dataset
uspto-grants-2011_01
Patent number
US07868001B2

Reaction notes

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