HCID 57686831, compound → HCID 57686802, compound

HRID 251819Notes

Reaction equation

HRID 251819 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:12]=[C:13]([CH:16]=[C:17]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:18]=3)[C:14]#[N:15])[N:10]=2)[N:7]=1>CO.[Pd]>[N:10]1[C:9]([C:11]2[CH:12]=[C:13]([CH:16]=[C:17]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:18]=2)[C:14]#[N:15])=[CH:8][N:6]2[C:5]=1[CH:4]=[CH:3][CH:2]=[N:7]2

Participants

4

Reactant 1

HCID 57686831HCID 57686831, compound

Product 1

HCID 57686802HCID 57686802, compoundYield 98.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)benzonitrile (10 mmol) in 100 ml MeOH was added Pd/C(1 mmol) and stirred at room temperature for 4 h. Pd-C was removed and the filtrate was concentrated to provide 3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)benzonitrile (98.9%).

Workup

  1. customPd-C was removed
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-cccfd2b0b06444d388973c5b7c980989
Source dataset
uspto-grants-2011_01
Patent number
US07868001B2

Reaction notes

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