反应详情

温度

60 °C

795 mg (3.61 mmol) of 2-methyl-4-(trifluoromethoxy)benzoic acid are heated with 4 ml (54.8 mmol) of thionyl chloride and a drop of DMF for 30 min under reflux. After cooling the reaction mixture is added slowly dropwise into an ice-cooled concentrated aqueous ammonia solution. The resulting precipitate is collected by suction filtration, taken up in 30 ml of water and stirred for 1 h at 60° C. The reaction mixture is left to cool, the solid is collected by filtration and dried under vacuum. Yield: 562 mg (71% of theory)

1. temperatureAfter cooling the reaction mixture
2. filtrationThe resulting precipitate is collected by suction filtration
3. waitThe reaction mixture is left
4. temperatureto cool
5. filtrationthe solid is collected by filtration
6. customdried under vacuum