HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isocyanatocyclopropane → HCID 66861132, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Isocyanatocyclopropane | HCID 637659 | — |
| Edukt | 1-Cyclopropyl-N-(2,4-dichlorobenzyl)-7-[(3RS,5SR)-3,5-dimethylpiperazin-1-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide | HCID 66859962 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | HCID 66861132 | HCID 66861132 | — |
Reaktionsschritte
30 μl (24.3 mg, 0.29 mmol) of cyclopropylisocyanate are dissolved in dichloromethan, 80.0 mg (0.146 mmol) of the compound of Example 12 are added and the mixture is stirred over night at room temperature. For the work-up the solvent is removed completely and after fine purification by preparative RP-HPLC (Method 6) 55 mg of the target compound are obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07867992B2 |
| Quelldatensatz | uspto-grants-2011_01 |
| ORD ID | ord-d9c6184ee2354d53a2328dc7ba903420 |
| Quellennotiz | uspto-grants-2011_01 |