反应详情

[2-((R)-6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl-carbamoyl]methyl acetate (180 mg) was dissolved in methanol (5 ml). With stirring, potassium carbonate (305 mg, finely powdered) was added and the mixture was then stirred efficiently at room temperature for 4 h. Subsequently, the solvent was evaporated off, and the residue was taken up in ethyl acetate and washed three times with water. The ethyl acetate phase was dried with magnesium sulfate, filtered and concentrated. 160 mg of the desired product were obtained.

1. stirringthe mixture was then stirred efficiently at room temperature for 4 h
2. customSubsequently, the solvent was evaporated off
3. washwashed three times with water
4. dry with materialThe ethyl acetate phase was dried with magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated