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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 251876Generated: October 27, 2026

2-Chloroethyl chloroformate → 3-[2-((R)-6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]oxazolidin-2-one

https://huagongshe.com/reaction/251876

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloroethyl chloroformateHCID 12305—
Reactant(R)-2-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamineHCID 66864574—
Product3-[2-((R)-6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]oxazolidin-2-oneHCID 11703546108.6%

Reaction Steps

Analogously to example 45a), (R)-2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)phenylamine (300 mg, enantiomer B, preparation as described in WO2004085404) was reacted with 2-chloroethyl chloroformate (140 mg). 400 mg of the desired product were obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07868003B2
Source datasetuspto-grants-2011_01
ORD IDord-15abb22acc9d4902b84699afde4fba8b
Source noteuspto-grants-2011_01