N-(2,3-Epoxypropyl)-N-ethylaniline → HCID 21312729, compound

Participants

Reaction Steps

A solution of ethyl-oxiranylmethyl-phenyl-amine (1.72 g, 9.65 nmol) and NaOMe (1.04 g, 2.0 eq.) in MeOH (8 mL) was heated at reflux for over weekend. After cooling to room temperature, the mixture was diluted with sat NaHCO3 (20 mL) and extracted with 3×20 mL of EtOAc. The combined extracts were dried over Na2SO4, filtered and concentrated and the product was purified by chromatography (30% EtOAc-hexanes) to give 1-(ethyl-phenyl-amino)-3-methoxy-propan-2-ol (1.95 g, 97%).

Provenance & Evidence