反应详情

A solution of ethyl-oxiranylmethyl-phenyl-amine (1.72 g, 9.65 nmol) and NaOMe (1.04 g, 2.0 eq.) in MeOH (8 mL) was heated at reflux for over weekend. After cooling to room temperature, the mixture was diluted with sat NaHCO3 (20 mL) and extracted with 3×20 mL of EtOAc. The combined extracts were dried over Na2SO4, filtered and concentrated and the product was purified by chromatography (30% EtOAc-hexanes) to give 1-(ethyl-phenyl-amino)-3-methoxy-propan-2-ol (1.95 g, 97%).

1. temperatureat reflux for over weekend
2. extractionextracted with 3×20 mL of EtOAc
3. dry with materialThe combined extracts were dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated
6. customthe product was purified by chromatography (30% EtOAc-hexanes)