反应详情

To a solution of cyclopentanone (25.0 mL, 0.28 mol. 1.0 eq.) in toluene (100 mL), was added pyrrolidine (27.5 mL, 1.2 eq.). The reaction was equipped with a Dean-Stark and heated at reflux overnight. The reaction mixture was cooled to room temperature and concentrated to give the crude 1-cyclopent-1-enyl-pyrrolidine (45.8 g, >100%).

1. customThe reaction was equipped with a Dean-Stark
2. temperatureheated
3. temperatureat reflux overnight
4. concentrationconcentrated