反应详情

Stir (S)-3-(2,4-dichlorobenzylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester (1.08 g, 3.13 mmol) in 20% trifluoroacetic acid in dichloromethane (10 mL) overnight. Concentrate and dissolve the residue in methanol (2 mL) and deposit onto an SCX-cartridge; eluting with methanol, then with 2 N ammonia in methanol. Concentrate the ammonia washing to give the title compound (630 mg, 82%).

1. concentrationConcentrate
2. dissolutiondissolve the residue in methanol (2 mL)
3. washeluting with methanol
4. concentrationConcentrate the ammonia washing