Ammonium Hydroxide → 5-Methoxypyridin-3-ylamine

HRID 252210노트

반응식

HRID 252210 반응식
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1.[NH4+:10].[OH-]>O.[O-]S([O-])(=O)=O.[Cu+2].O>[CH3:9][O:8][C:6]1[CH:7]=[C:2]([NH2:10])[CH:3]=[N:4][CH:5]=1

참가 물질

5

반응물 2

HCID 14923Ammonium HydroxideHCID 8171633-Bromo-5-methoxypyridine

생성물 1

HCID 127035955-Methoxypyridin-3-ylamine

시약·촉매·용매 2

HCID 61499Cupric sulfate monohydrate촉매HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

A solution of 3-bromo-5-methoxypyridine (5.2 g, 27.5 mmol) and CuSO4.H2O (1.37 g, 5.5 mmol) in NH4OH (5 mL) was placed in a sealed tube and heated at 120° C. for 10 hours. The reaction mixture was then cooled to room temperature, diluted with H2O (40 mL), and extracted with EtOAc (3×30 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated to afford the title compound that was used in the next step with no further purification.

후처리

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. extractionextracted with EtOAc (3×30 mL)
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e31b3fe920094371837351538f9ad015
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07868026B2

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