関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 3-Bromo-5-methoxypyridine | HCID 817163 | — |
| 触媒 | Cupric sulfate monohydrate | HCID 61499 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Methoxypyridin-3-ylamine | HCID 12703595 | — |
反応手順
A solution of 3-bromo-5-methoxypyridine (5.2 g, 27.5 mmol) and CuSO4.H2O (1.37 g, 5.5 mmol) in NH4OH (5 mL) was placed in a sealed tube and heated at 120° C. for 10 hours. The reaction mixture was then cooled to room temperature, diluted with H2O (40 mL), and extracted with EtOAc (3×30 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated to afford the title compound that was used in the next step with no further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07868026B2 |
|---|
| 出典データセット | uspto-grants-2011_01 |
|---|
| ORD ID | ord-e31b3fe920094371837351538f9ad015 |
|---|
| 出典メモ | uspto-grants-2011_01 |
|---|
