2-Bromo-3-methylthiophene → 2-Methoxy-5-(3-methyl-thiophen-2-yl)-pyridine

HRID 252257Notes

Reaction equation

HRID 252257 reaction equation
Br[C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH3:7].[CH3:8][O:9][C:10]1[CH:15]=[CH:14][C:13](B(O)O)=[CH:12][N:11]=1>>[CH3:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:2]2[S:3][CH:4]=[CH:5][C:6]=2[CH3:7])=[CH:12][N:11]=1

Participants

3

Reactant 2

HCID 843142-Bromo-3-methylthiopheneHCID 2734368(6-Methoxypyridin-3-yl)boronic acid

Product 1

HCID 112065202-Methoxy-5-(3-methyl-thiophen-2-yl)-pyridine

Procedure

The title intermediate, MS: m/e 206.1 (MH+), was prepared analogously to Example 52 from 2-bromo-3-methyl-thiophene and 2-methoxy-5-pyridineboronic acid.

Sources & evidence

ORD record
ord-cf61eba40ad641bc869bba9269acbf4c
Source dataset
uspto-grants-2011_01
Patent number
US07868030B2

Reaction notes

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