3,5-Difluorobenzaldehyde → HCID 66842583, compound

HRID 252330Notes

Reaction equation

HRID 252330 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:17][CH3:18])[C:13]=1[CH2:14][CH2:15][CH3:16])[CH2:6]P(=O)([O-])[O-].[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[C:26]([F:28])[CH:27]=1)[CH:23]=O>>[F:19][C:20]1[CH:21]=[C:22]([CH:23]=[CH:6][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:13]([CH2:14][CH2:15][CH3:16])=[C:12]([O:17][CH3:18])[CH:11]=2)[CH:25]=[C:26]([F:28])[CH:27]=1

Participants

3

Reactant 2

HCID 5881603,5-DifluorobenzaldehydeHCID 86597115HCID 86597115, compound

Product 1

HCID 66842583HCID 66842583, compoundYield 27%

Procedure

This material was prepared from (3,5-dimethoxy-4-1-propylbenzyl)phosphonate and 3,5-difluorobenzaldehyde in 27% yield in the same way as described in Example 21. 1HNMR (CDCl3, ppm): δ 1.32 (d, J=7.0 Hz, 6H), 3.66 (qint., J=7.0 Hz, 1H), 3.90 (s, 6H), 6.72 (s, 2H), 6.8-7.2 (m, 5H).

Sources & evidence

ORD record
ord-9e2b48e045aa4be1bbf85524109fd7cf
Source dataset
uspto-grants-2011_01
Patent number
US07868047B2

Reaction notes

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