Methyl 4-methoxybutanoate → HCID 66888453, compound

HRID 252354Notes

Reaction equation

HRID 252354 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][NH2:9])=[N:6][CH:7]=1.[CH3:10][O:11][CH2:12][CH2:13][CH2:14][C:15](OC)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:15]([CH2:14][CH2:13][CH2:12][O:11][CH3:10])=[N:9][N:8]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 542317Methyl 4-methoxybutanoateHCID 115356995-Bromo-2-hydrazinopyridine

Product 1

HCID 66888453HCID 66888453, compound

Procedure

A mixture of 18.80 g of (5-bromopyridin-2-yl)hydrazine [77992-44-0] and 14.54 g of methyl 4-methoxybutyrate [29006-01-7] is heated to reflux over 16 hours. The reaction solution is subsequently cooled and purified by means of flash chromatography (SiO2 60F). The title compound is identified on the basis of the Rf value.

Workup

  1. temperatureis heated
  2. temperatureto reflux over 16 hours
  3. temperatureThe reaction solution is subsequently cooled
  4. custompurified by means of flash chromatography (SiO2 60F)

Sources & evidence

ORD record
ord-5ff049fd4acc42c1a6ba190671a246db
Source dataset
uspto-grants-2011_01
Patent number
US07868036B2

Reaction notes

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