反应详情

21.7 g (0.095 mol) of glycidyl tosylate, 10 g (0.0475 mol) of 2-amino-3-nitrophenol and 6.5 g of crushed K2CO3 are mixed in acetone and the mixture is heated at reflux for 18 hours. The mixture is filtered and the solvent is evaporated under reduced pressure. The crude reaction product is purified by flash chromatography, elution being carried out with a 9/1 hexane/ethyl acetate mixture. The title compound is obtained. M.p.: 7°-78° C.

1. temperaturethe mixture is heated
2. temperatureat reflux for 18 hours
3. filtrationThe mixture is filtered
4. customthe solvent is evaporated under reduced pressure
5. customThe crude reaction product
6. customis purified by flash chromatography, elution