Dimethylamine → HCID 178500373, compound

HRID 252391Notes

Reaction equation

HRID 252391 reaction equation
[CH3:1][O:2][C:3](=[O:24])[C:4]([CH3:23])([C@H:6]1[CH2:11][CH2:10][C@H:9](OS(C2C=CC(C)=CC=2)(=O)=O)[CH2:8][CH2:7]1)[CH3:5].[CH3:25][NH:26][CH3:27]>>[CH3:1][O:2][C:3](=[O:24])[C:4]([C@H:6]1[CH2:11][CH2:10][C@@H:9]([N:26]([CH3:27])[CH3:25])[CH2:8][CH2:7]1)([CH3:23])[CH3:5]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 178500380HCID 178500380, compound

Product 1

HCID 178500373HCID 178500373, compound

Procedure

A solution of 0.354 g of trans-2-methyl-2-[4-(toluene-4-sulfonyloxy)-cyclohexyl]-propionic acid methyl ester in 10 ml of 60% aqueous dimethylamine solution is heated to 110° C. for 48 hours. The reactions mixture is cooled to room temperature and extracted with dichloromethane (3×). The combined extracts are dried over sodium sulphate and concentrated. Flash chromatography (SiO2 60F) of the residue provides the title compound which is identified on the basis of its Rf-value.

Workup

  1. extractionextracted with dichloromethane (3×)
  2. dry with materialThe combined extracts are dried over sodium sulphate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-a26602f50374425bb474b5a13a029a8b
Source dataset
uspto-grants-2011_01
Patent number
US07868036B2

Reaction notes

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