Dimethylamine → HCID 178500373, compound

Participants

Reaction Steps

A solution of 0.354 g of trans-2-methyl-2-[4-(toluene-4-sulfonyloxy)-cyclohexyl]-propionic acid methyl ester in 10 ml of 60% aqueous dimethylamine solution is heated to 110° C. for 48 hours. The reactions mixture is cooled to room temperature and extracted with dichloromethane (3×). The combined extracts are dried over sodium sulphate and concentrated. Flash chromatography (SiO2 60F) of the residue provides the title compound which is identified on the basis of its Rf-value.

Provenance & Evidence