2-Chloro-4-(trifluoromethyl)pyrimidine → N-(4-cyano-1-methyl-piperidin-4-yl)-2-(4-trifluoromethyl-pyrimidin-2-ylamino)-3-cyclohexyl-propionamide
Reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][N:3]=1.[NH2:12][CH:13]([CH2:26][CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[C:14]([NH:16][C:17]1([C:24]#[N:25])[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)=[O:15]>>[C:24]([C:17]1([NH:16][C:14](=[O:15])[CH:13]([NH:12][C:2]2[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][N:3]=2)[CH2:26][CH:27]2[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]2)[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]1)#[N:25]Participants
3
Procedure
The title compound was prepared from 2-chloro-4-trifluoromethyl pyrimidine and 2-amino-N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-propionamide according to the procedure from Example 19. MS, m/z 439.5=M+1.
Sources & evidence
- ORD record
- ord-b66c3efcf9364c67b55dbd1f48029e72
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06858623B2
Reaction notes
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