5-Fluoro-2-(4'-amino-3'-iodophenyl)benzothiazole → 2-Amino-5-(5-fluorobenzo[d]thiazol-2-yl)benzonitrile

Participants

Reaction Steps

5-Fluoro-2-(4′-amino-3′-iodophenyl)benzothiazole (5 g, 0.0135 mol), copper cyanide (3.65 g, 0.04 mol) and DMF (100 ml) were heated under reflux for 6 hrs, cooled and the solvent removed under vacuum. The residue was stirred in water (50 ml) for 30 mins, then the product extracted with ethyl acetate (2×100 ml). The combined extracts were dried (Na2SO4), evaporated and the residue recrystallised from ethanol to give a white solid.

Provenance & Evidence