反应详情

5-Fluoro-2-(4′-amino-3′-iodophenyl)benzothiazole (5 g, 0.0135 mol), copper cyanide (3.65 g, 0.04 mol) and DMF (100 ml) were heated under reflux for 6 hrs, cooled and the solvent removed under vacuum. The residue was stirred in water (50 ml) for 30 mins, then the product extracted with ethyl acetate (2×100 ml). The combined extracts were dried (Na2SO4), evaporated and the residue recrystallised from ethanol to give a white solid.

1. temperatureunder reflux for 6 hrs
2. temperaturecooled
3. customthe solvent removed under vacuum
4. extractionthe product extracted with ethyl acetate (2×100 ml)
5. dry with materialThe combined extracts were dried (Na2SO4)
6. customevaporated
7. customthe residue recrystallised from ethanol
8. customto give a white solid