Morpholine → Pyridine-3-sulfonyl chloride

HRID 252702Notes

Reaction equation

HRID 252702 reaction equation
Br[C:2]1[CH:3]=[C:4]([S:8]([Cl:11])(=[O:10])=[O:9])[CH:5]=[N:6][CH:7]=1.N1CCOCC1>>[N:6]1[CH:7]=[CH:2][CH:3]=[C:4]([S:8]([Cl:11])(=[O:10])=[O:9])[CH:5]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 203244745-Bromopyridine-3-sulfonyl chloride

Product 1

HCID 3164136Pyridine-3-sulfonyl chlorideYield 13%

Procedure

Using an analogous method to that described in the portion of Example 8 that is concerned with the preparation of starting materials, 5-bromopyridine-3-sulfonyl chloride was reacted with morpholine to give the required starting material (90 mg, 13% yield from the pyridine-3-sulfonyl chloride); Mass Spectrum: M+H+ 350 and 352.

Sources & evidence

ORD record
ord-76d1e5968c5f4e1f8ec5773f376776ee
Source dataset
uspto-grants-2011_01
Patent number
US07868188B2

Reaction notes

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