Hydrochloric Acid → HCID 86620393, compound

HRID 252717Notes

Reaction equation

HRID 252717 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([NH:13]C(=O)C)=[N:10][C:9]=2[CH3:17])=[CH:4][C:3]=1[NH:18][S:19]([C:22]1[S:26][C:25]([CH3:27])=[N:24][C:23]=1[CH3:28])(=[O:21])=[O:20].Cl>>[NH2:13][C:11]1[S:12][C:8]([C:5]2[CH:4]=[C:3]([NH:18][S:19]([C:22]3[S:26][C:25]([CH3:27])=[N:24][C:23]=3[CH3:28])(=[O:21])=[O:20])[C:2]([Cl:1])=[N:7][CH:6]=2)=[C:9]([CH3:17])[N:10]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11683972HCID 11683972, compound

Product 1

HCID 86620393HCID 86620393, compound

Procedure

Using an analogous procedure to that described in Example 61, N-{5-[6-chloro-5-(2,4-dimethyl-1,3-thiazol-5-ylsulfonamido)pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl}acetamide was hydrolysed with aqueous hydrochloric acid solution to give the title compound; 1H NMR Spectrum: (DMSOd6) 2.18 (s, 3H), 2.35 (s, 3H), 2.61 (s, 3H), 7.30 (s, 2H), 7.64 (d, 11H), 8.22 (s, 1H), 10.80 (br s, 1H); Mass Spectrum: M+H+ 416.

Sources & evidence

ORD record
ord-dd31cde804db4041a14dc3553573998f
Source dataset
uspto-grants-2011_01
Patent number
US07868188B2

Reaction notes

Loading…