4-Cyanobenzenesulfonyl chloride → HCID 86620408, compound

HRID 252732Notes

Reaction equation

HRID 252732 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:12][C:11]([NH:13][C:14](=[O:16])[CH3:15])=[N:10][C:9]=2[CH3:17])=[N:6][CH:7]=1.[C:18]([C:20]1[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=1)#[N:19]>>[C:18]([C:20]1[CH:21]=[CH:22][C:23]([S:26]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[S:12][C:11]([NH:13][C:14](=[O:16])[CH3:15])=[N:10][C:9]=3[CH3:17])=[N:6][CH:7]=2)(=[O:28])=[O:27])=[CH:24][CH:25]=1)#[N:19]

Participants

3

Reactant 2

HCID 394974-Cyanobenzenesulfonyl chlorideHCID 86244444HCID 86244444, compound

Product 1

HCID 86620408HCID 86620408, compound

Procedure

Using an analogous procedure to that described in Example 83, N-[5-(5-aminopyridin-2-yl)-4-methyl-1,3-thiazol-2-yl]acetamide was reacted with 4-cyanophenylsulfonyl chloride to give the title compound; 1H NMR Spectrum: (DMSOd6) 2.14 (s, 3H), 2.48 (s, 3H), 7.57 (m, 2H), 7.94 (d, 2H), 8.07 (d, 2H), 8.26 (m, 1H), 10.86 (br s, 1H), 12.06 (s, 1H); Mass Spectrum: M+H+ 414.

Sources & evidence

ORD record
ord-0dbea3e4b23f4877b9105b43cd5e1940
Source dataset
uspto-grants-2011_01
Patent number
US07868188B2

Reaction notes

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