反应详情

Pd/C 10% was added to a suspension of 260 (200 mg, 0.68 mmol) in MeOH (40 ml) and DMA (10 ml) which was previously purged under vacuum. The reaction mixture was stirred during 4 h at room temperature. After evaporation of the MeOH, water was added to the oily residue and the precipitate obtained was filtered. The crude residue was then purified by flash chromatography on silica gel (5-8% AcOEt/Hex) to afford the title compound 263 (114 mg, 59%) as a white solid. LRMS: 282.1 (Calc.); 283.0 (found).

1. customwas previously purged under vacuum
2. customAfter evaporation of the MeOH, water
3. additionwas added to the oily residue
4. customthe precipitate obtained
5. filtrationwas filtered
6. customThe crude residue was then purified by flash chromatography on silica gel (5-8% AcOEt/Hex)