Hydrochloric Acid → HCID 66863472, compound

HRID 252931Notes

Reaction equation

HRID 252931 reaction equation
[ClH:1].[S:2]1[CH:6]=[CH:5][N:4]=[C:3]1[N:7]1[CH2:11][CH2:10][CH:9]([NH:12]C(=O)OC(C)(C)C)[CH2:8]1>CO>[ClH:1].[S:2]1[CH:6]=[CH:5][N:4]=[C:3]1[N:7]1[CH2:11][CH2:10][CH:9]([NH2:12])[CH2:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66863318HCID 66863318, compound

Product 1

HCID 66863472HCID 66863472, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Aq. conc. hydrochloric acid (2 ml) was added to a solution of 890 mg (3.3 mmol) of tert.-butyl 1-(thiazol-2-yl)pyrrolidin-3-ylcarbamate in MeOH (20 ml). The reaction solution was stirred at RT for 16 h and then evaporated under a vacuum. 653 mg (3.2 mmol, 97%) of 1-(thiazol-2-yl)pyrrolidin-3-amine hydrochloride were obtained by crystallising the residue from an ethanol/ether mixture.

Workup

  1. customevaporated under a vacuum

Sources & evidence

ORD record
ord-75eaeb34a0be4c16aae5ba04a60c61d3
Source dataset
uspto-grants-2011_01
Patent number
US07871999B2

Reaction notes

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