Trifluoroacetic acid → HCID 66863167, compound

HRID 252940Notes

Reaction equation

HRID 252940 reaction equation
[F:1][C:2]1[S:6][C:5]([N:7]([CH3:20])[CH:8]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)=[N:4][CH:3]=1.[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>C(Cl)Cl>[F:24][C:23]([F:26])([F:25])[C:21]([OH:27])=[O:22].[F:1][C:2]1[S:6][C:5]([N:7]([CH3:20])[CH:8]2[CH2:12][CH2:11][NH:10][CH2:9]2)=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66862509HCID 66862509, compound

Product 1

HCID 66863167HCID 66863167, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 590 mg (1.96 mmol) tert.-butyl 3-((5-fluorothiazol-2-yl)(methyl)amino)-pyrrolidine-1-carboxylate in DCM (10 ml) was combined with 5 ml of TFA and stirred for 1 h at RT. The mixture was then evaporated under a vacuum, redissolved with MeOH and again evaporated, 611 mg (1.94 mmol, 99%) of 5-fluoro-N-methyl-N-(pyrrolidin-3-yl)thiazol-2-amine trifluoroacetate being obtained which were further reacted without being purified.

Workup

  1. customThe mixture was then evaporated under a vacuum
  2. dissolutionredissolved with MeOH
  3. customagain evaporated

Sources & evidence

ORD record
ord-124664187ba44e48b4f55fed1ebcecf1
Source dataset
uspto-grants-2011_01
Patent number
US07871999B2

Reaction notes

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