1-Methylpiperazine → HCID 178480643, compound

HRID 252949Notes

Reaction equation

HRID 252949 reaction equation
C1(N2C(=O)C3=CNC4C=[CH:15][C:16]([N:19]5[CH2:24]CN[CH2:21][CH2:20]5)=CC=4C3=N2)C=CC=CC=1.[NH2:27][C:28]1[CH:37]=[CH:36][C:35]2[NH:34][CH:33]=[C:32]3[C:38](=[O:48])[N:39]([C:41]4[CH:46]=[CH:45][C:44]([Cl:47])=[CH:43][CH:42]=4)[N:40]=[C:31]3[C:30]=2[CH:29]=1.CN1CCNCC1>>[Cl:47][C:44]1[CH:43]=[CH:42][C:41]([N:39]2[C:38](=[O:48])[C:32]3=[CH:33][NH:34][C:35]4[CH:36]=[CH:37][C:28]([N:27]5[CH2:21][CH2:20][N:19]([CH3:24])[CH2:16][CH2:15]5)=[CH:29][C:30]=4[C:31]3=[N:40]2)=[CH:46][CH:45]=1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 178507348HCID 178507348, compoundHCID 178515209HCID 178515209, compound

Product 1

HCID 178480643HCID 178480643, compound

Procedure

The title compound was prepared following the procedure described for 7a using 6b and 1-methyl-piperazine. 1H-NMR (DMSO-d6) δ (ppm): 3.25 (4H, br), 3.50 (7H, br), 3.75 (3H, s), 7.00 (1H, d, J=9.06 Hz), 7.40 (1H, m), 7.48 (1H, br), 7.68 (1H, d, J=9.06 Hz), 7.92 (1H, d, J=8.79 Hz), 8.05 (2H, d, J=8.79 Hz), 8.56 (1H, br), 9.12 (1H, br). m/z 394.9 (MH+).

Sources & evidence

ORD record
ord-a3ef9cdc6868486fb81d0f854100047e
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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