2,6-Dimethylmorpholine → HCID 178429838, compound

HRID 252967Notes

Reaction equation

HRID 252967 reaction equation
FC1C(N2CCNCC2)=CC2NC=C3C(=O)N(C4C=CC=CC=4)N=C3C=2C=1.F[C:29]1[C:30]([F:49])=[CH:31][C:32]2[C:33]3[C:34]([C:39](=[O:48])[N:40]([C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)[N:41]=3)=[CH:35][NH:36][C:37]=2[CH:38]=1.[CH3:50][CH:51]1[O:56][CH:55]([CH3:57])[CH2:54][NH:53][CH2:52]1>>[CH3:57][CH:55]1[O:56][CH:51]([CH3:50])[CH2:52][N:53]([C:29]2[C:30]([F:49])=[CH:31][C:32]3[C:33]4[C:34]([C:39](=[O:48])[N:40]([C:42]5[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=5)[N:41]=4)=[CH:35][NH:36][C:37]=3[CH:38]=2)[CH2:54]1

Participants

4

Reactant 3

HCID 1108622,6-DimethylmorpholineHCID 178515218HCID 178515218, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178429838HCID 178429838, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27a and 2,6-dimethylmorpholine. 1H-NMR (DMSO-d6) δ (ppm): 1.15 (6H, d, J=6.73 Hz), 2.40 (2H, brm), 3.41 (2H, d, J=10.99 Hz), 3.76 (2H, brm), 7.13 (1H, m), 7.26 (1H, d, J=7.69 Hz), 7.41 (2H, t, J=7.42 Hz), 7.83 (2H, d, J=12.91 Hz), 8.19 (2H, m), 8.66 (1H, s). m/z 393.4 (MH+).

Sources & evidence

ORD record
ord-56cab3999ce24335ac00a2380408df05
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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