Piperazine → HCID 178515227, compound

HRID 252972Notes

Reaction equation

HRID 252972 reaction equation
[F:1][C:2]1[C:11]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:18](=[O:27])[N:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[N:20]=[C:5]3[C:4]=2[CH:3]=1.[F:28]C1C(F)=CC2C3C(C(=O)N(C4C=CC=CC=4F)N=3)=CNC=2C=1.N1CCNCC1>>[F:1][C:2]1[C:11]([N:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:18](=[O:27])[N:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[F:28])[N:20]=[C:5]3[C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 4837PiperazineHCID 178515219HCID 178515219, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178515227HCID 178515227, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27c and piperazine. 1H-NMR (CD3OD) δ (ppm): 3.01 (4H, brm), 3.34 (4H, brm), 7.05 (1H, d, J=7.7 Hz), 7.16 (2H, m), 7.31 (1H, m), 7.40 (1H, m), 7.66 (1H, d, J=13.1 Hz), 8.44 (1H, s). m/z 382.2

Sources & evidence

ORD record
ord-6228c0b02499417180876f61cc99d717
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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