1-Methylpiperazine → HCID 178480616, compound

HRID 252973Notes

Reaction equation

HRID 252973 reaction equation
FC1[C:11]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=CC2NC=C3C(=O)N(C4C=CC=CC=4)N=C3C=2C=1.F[C:29]1[C:30]([F:50])=[CH:31][C:32]2[C:33]3[C:34]([C:39](=[O:49])[N:40]([C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=4[F:48])[N:41]=3)=[CH:35][NH:36][C:37]=2[CH:38]=1.CN1CCNCC1>>[F:50][C:30]1[C:29]([N:15]2[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)=[CH:38][C:37]2[NH:36][CH:35]=[C:34]3[C:39](=[O:49])[N:40]([C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=4[F:48])[N:41]=[C:33]3[C:32]=2[CH:31]=1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 178515219HCID 178515219, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178480616HCID 178480616, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27c and 1-methylpiperazine. 1H-NMR (CD3OD) δ (ppm): 2.23 (3H, s), 2.48 (4H, brm), 2.68 (4H, brm), 7.05 (1H, d, J=7.7 Hz), 7.16 (2H, m), 7.31 (1H, m), 7.40 (1H, m), 7.66 (1H, d, J=13.1 Hz), 8.44 (1H, s). m/z 396.2

Sources & evidence

ORD record
ord-b02b4dfc66fb46e2a4eb96e89ba3b4bc
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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