Piperazine → HCID 178515228, compound

HRID 252974Notes

Reaction equation

HRID 252974 reaction equation
[F:1][C:2]1[C:11]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:18](=[O:27])[N:19]([C:21]4[CH:26]=[CH:25]C=C[CH:22]=4)[N:20]=[C:5]3[C:4]=2[CH:3]=1.FC1C(F)=CC2C3C(C(=O)N(C4C=C[S:44]C=4)N=3)=CNC=2C=1.N1CCNCC1>>[F:1][C:2]1[C:11]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:18](=[O:27])[N:19]([C:21]4[CH:26]=[CH:25][S:44][CH:22]=4)[N:20]=[C:5]3[C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 4837PiperazineHCID 178515220HCID 178515220, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178515228HCID 178515228, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27d and piperazine. 1H-NMR (DMSO-d6) δ (ppm): 2.92 (4H, brm), 3.05 (4H, brm), 7.21 (1H, m), 7.58 (1H, m), 7.79 (3H, m), 8.67 (1H, m). m/z 370.2

Sources & evidence

ORD record
ord-7f798d5414b24314ae47cec734a0c744
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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