反应详情

温度

-78 °C

2-Methyl-4-chloro-6-morpholino-pyridine (50 mmol) is dissolved in tetrahydrofuran (200 mL). The reaction is chilled to −78° C. under an inert atmosphere. A solution of n-butyllithium in hexanes (24 mL, 2.5M, 60 mmol) is added, and the reaction mixture is stirred for thirty minutes. A solution of oxirane dissolved in tetrahydrofuran (40 mL, 41.5M, 60 mmol) is added, and the reaction is allowed to warm to room temperature while stirring overnight. The solvent is removed under reduced pressure, and the crude material is dissolved in methylene chloride (200 mL) and washed with saturated ammonium chloride (2×50 mL), dried with sodium sulfate, and evaporated to dryness. The compound is purified by column chromatography to give 3-(4-chloro-6-morpholin-4-yl-pyrid-2-yl)-propan-1-ol.

1. additionis added
2. temperatureto warm to room temperature
3. stirringwhile stirring overnight
4. customThe solvent is removed under reduced pressure
5. dissolutionthe crude material is dissolved in methylene chloride (200 mL)
6. washwashed with saturated ammonium chloride (2×50 mL)
7. dry with materialdried with sodium sulfate
8. customevaporated to dryness
9. customThe compound is purified by column chromatography