Hydrogen Bromide → HCID 135863375, compound

HRID 253019Notes

Reaction equation

HRID 253019 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([C:9]2[NH:10][C:11](=[O:18])[C:12]3[S:17][CH:16]=[CH:15][C:13]=3[N:14]=2)[CH:6]=[CH:7][CH:8]=1.Br>C(O)(=O)C.O>[OH:2][C:3]1[CH:4]=[C:5]([C:9]2[NH:10][C:11](=[O:18])[C:12]3[S:17][CH:16]=[CH:15][C:13]=3[N:14]=2)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 1357964662-(3-methoxy-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one

Product 1

HCID 135863375HCID 135863375, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

To a suspension of 2-(3-methoxy-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one (30.31 g, 0.12 mol) in acetic acid (170 mL) was added 48% aqueous hydrogen bromide (170 mL) and the mixture heated under reflux for 48 hours. The mixture was then cooled in ice-water and diluted with water (200 mL). The grey solid was collected by filtration, washed with water and dried to give compound 3 (28.58 g, 100%).

Workup

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 48 hours
  3. filtrationThe grey solid was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-20a1751c415749258ea5feab9b1d3c63
Source dataset
uspto-grants-2011_01
Patent number
US07872003B2

Reaction notes

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