反应详情

To a suspension of 2-(3-methoxy-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one (30.31 g, 0.12 mol) in acetic acid (170 mL) was added 48% aqueous hydrogen bromide (170 mL) and the mixture heated under reflux for 48 hours. The mixture was then cooled in ice-water and diluted with water (200 mL). The grey solid was collected by filtration, washed with water and dried to give compound 3 (28.58 g, 100%).

1. temperaturethe mixture heated
2. temperatureunder reflux for 48 hours
3. filtrationThe grey solid was collected by filtration
4. washwashed with water
5. customdried