Lithium Hydroxide → HCID 66844822, compound

HRID 253149Notes

Reaction equation

HRID 253149 reaction equation
[C:1]1([C@H:7]([NH:9][C:10]([N:12]2[CH2:17][CH:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:15][CH:14]([C:24]([O:26]C)=[O:25])[CH2:13]2)=[O:11])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Li+].[OH-]>C1COCC1.CO>[C:1]1([C@H:7]([NH:9][C:10]([N:12]2[CH2:17][CH:16]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:15][CH:14]([C:24]([OH:26])=[O:25])[CH2:13]2)=[O:11])[CH3:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66844638HCID 66844638, compound

Product 1

HCID 66844822HCID 66844822, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

To a 150 mL RBF was added the mixture from step 1 (150 mg), THF:MeOH (3:1, 15 mL), and LiOH, 1M (1.00 ml, 1.0 mmol) and the mixture was stirred at RT. After 2 hours, the reaction was neutralized and extracted with EtOAc (3×20 mL). The combined organic layers were concentrated in vacuo to give a white solid. The material was carried forward without further purification.

Workup

  1. extractionextracted with EtOAc (3×20 mL)
  2. concentrationThe combined organic layers were concentrated in vacuo
  3. customto give a white solid
  4. customThe material was carried forward without further purification

Sources & evidence

ORD record
ord-1707480d73ac4e1ab4bf71d7028004fe
Source dataset
uspto-grants-2011_01
Patent number
US07872009B2

Reaction notes

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