反应详情

温度

5 °C

Cool (0° C.) a solution of lithium aluminum hydride (5.3 mL, IM in THF) and add a solution of [5-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-acetic acid ethyl ester (Example 1, 1.4 g, 4.25 mmol) in THF (15 mL). On complete addition, remove the cold bath and stir for 2 hrs. Cool this solution to 5° C., and then add water (0.2 mL), dropwise, followed by NaOH solution (0.2 mL, 5M in water) and water (0.2 mL). Dilute the resulting mixture with ethyl acetate and then filter through a pad of celite. Wash the solids with dichloromethane and then concentrate the combined filtrates under reduced pressure. Purify the residue by flash chromatography (elute with 30% ethyl acetate 40% dichloromethane in heptane) to give the title compound as a yellow solid (0.879 g) Use the compound of Example 1 as the starting material to obtain the title compound.

1. additionOn complete addition
2. customremove the cold bath
3. additionDilute the resulting mixture with ethyl acetate
4. filtrationfilter through a pad of celite
5. washWash the solids with dichloromethane
6. concentrationconcentrate the combined filtrates under reduced pressure
7. customPurify the residue
8. washby flash chromatography (elute with 30% ethyl acetate 40% dichloromethane in heptane)