Methanol → HCID 58086875, compound

HRID 253383Notes

Reaction equation

HRID 253383 reaction equation
[OH-].[K+].[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[CH:5]=[CH:4]1.[CH2:12]([O:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=[O:25])=[CH:22][C:21]=1[O:28][CH3:29])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH3:30]O>>[CH2:12]([O:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]([O:25][CH3:30])[C:5]2[C:6]3[C:11](=[N:10][CH:9]=[CH:8][CH:7]=3)[NH:3][CH:4]=2)=[CH:22][C:21]=1[O:28][CH3:29])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

5

Reactant 4

HCID 887MethanolHCID 92221H-Pyrrolo(2,3-b)pyridineHCID 14797Potassium HydroxideHCID 755064-(Benzyloxy)-3-methoxybenzaldehyde

Product 1

HCID 58086875HCID 58086875, compound

Procedure

Methanol (125 mL) and potassium hydroxide (4.4 g, 79 mmol) were mixed with 1H-pyrrolo[2,3-b]pyridine (6, 3.1 g, 26.6 mmol) and 4-benzyloxy-3-methoxy-benzaldehyde (33, 12.9 g, 53.2 mmol). The reaction was stirred at room temperature for 2 days. The resulting white solid was filtered and washed with water, Crude material was carried forward without further purification.

Workup

  1. filtrationThe resulting white solid was filtered
  2. washwashed with water, Crude material
  3. customwas carried forward without further purification

Sources & evidence

ORD record
ord-295644fbaae142f1bbc017ff27f391f3
Source dataset
uspto-grants-2011_01
Patent number
US07872018B2

Reaction notes

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